Mantle cell lymphoma cells express predominantly cyclin D1a isoform and are highly sensitive to selective inhibition of CDK4 kinase activity
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Mantle cell lymphoma cells express predominantly cyclin D1a isoform and are highly sensitive to selective inhibition of CDK4 kinase activity.
The prognosis for patients with mantle cell lymphoma (MCL) is poor, and at present there is no truly effective therapy. Gene translocation-mediated constitutive expression of cyclin D1 seems to play the key role in the pathogenesis of MCL. Here we report that although 3 of 4 MCL cell lines expressed the recently identified, highly oncogenic cyclin D1b isoform, as well as the canonical cyclin D1...
متن کاملare highly sensitive to selective inhibition of CDK 4 kinase activity Mantle cell lymphoma cells express predominantly Cyclin D 1 a isoform
Mantle cell lymphoma (MCL) has a rather poor prognosis and currently no truly effective therapy. Gene translocation-mediated constitutive expression of Cyclin D1 seems to play the key role in the pathogenesis of MCL. Here we report that whereas three out of four MCL cell lines expressed the recently identified, highly oncogenic Cyclin D1b isoform, in addition to the canonical Cyclin D1a , eight...
متن کاملSelective CDK4/6 inhibition with tumor responses by PD0332991 in patients with mantle cell lymphoma.
Mantle cell lymphoma (MCL) carries an unfavorable prognosis and requires new treatment strategies. The associated t(11:14) translocation results in enhanced cyclin D1 expression and cyclin D1-dependent kinase activity to promote cell-cycle progression. A pharmacodynamic study of the selective CDK4/6 inhibitor PD0332991 was conducted in 17 patients with relapsed disease, using 2-deoxy-2-[(18)F]f...
متن کاملTargeting cyclin D1 for mantle cell lymphoma
Cyclin D1, an important component of cell cycle and a protein with known oncogenic potential, is over expressed in mantle cell lymphoma (MCL). MCL is a distinct clinical pathologic subtype of B cell non-Hodgkin’s lymphoma often associated with poor prognosis. New therapeutic approaches based on boosting anti-tumor immunity are being developed. Targeting cyclin D1 for MCL is rendering an interes...
متن کاملCyclin D1-negative mantle cell lymphoma.
In this issue of Blood, Salaverria et al report that more than half of Cyclin D1- (CCND1) negative SOX11-positive mantle cell lymphoma (MCL) had CCND2 gene rearrangement predominantly with immunoglobulin (IG) light chain genes.(1)
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ژورنال
عنوان ژورنال: Blood
سال: 2006
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2006-04-016634